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Comment: [Original edit by JustinMason]
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    No Spam Today! POP3 Proxy for Workstations - \[http://www.nospamtoday.com/workstation\] - With just a few mouse-clicks, No Spam Today! is configured to run on any Windows™ 98SE/ME/2000/NT/XP/2003 system. No Spam Today! easily connects to any POP3 email client. It additionally provides a wizard to enable spam protection for all your Outlook™ POP3 mail accounts.
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    PYTHEAS _MailGate_: POP3 gateway for Microsoft Exchange and Lotus Domino - \[http://www.pytheas.com/pmgen.asp\] - spam check with [SpamAssassin], anti-virus scanner interface, rules based content checking, optional outgoing mail handling.
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  • SAProxy - see the SaProxy page.
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    [SpamMover] for Exchange 2000/2003 - \[http://www.ivasoft.biz/spammover.shtml\]: 'this application can create a folder named Spam in each Exchange 2000/2003 mailbox and move any ingoing message that is marked with specific mail header by anti-spam software like [SpamAssassin], to that folder.'
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    Spamnix is 'the leading spam-blocking solution for Qualcomm Eudora on Windows and MacOS X' - \[http://www.spamnix.com/\]
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Linux

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    Kerio Mailserver for Windows and Linux - \[http://www.kerio.com/kms_home.html\] - (see above)
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    Roaring Penguin Software's [CanIt] - \[http://www.canit.ca/\]
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    Opencomputing Technologies [OpenProtect] - virus/spam e-mail filter gateway for Linux/BSD - \[http://opencompt.com\]
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MacOS X

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    Spamnix is 'the leading spam-blocking solution for Qualcomm Eudora on Windows and MacOS X' - \[http://www.spamnix.com/\]
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Network Appliances

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    Barbedwire Technologies' Deep Packet Inspector - \[http://www.barbedwiretech.com\].  This appears to be a Linux-based appliance which includes 'No Spam Today!' and '12 other security prevention tools'.
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    Barracuda Spam Firewall - \[http://www.barracudanetworks.com\]
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    NAI [SpamKiller] for [WebShield] Appliances - \[http://www.nai.com/us/products/mcafee/antispam/spk_webshield_appliances.htm\]
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    Digitalinfo Networks [MailPoint] - \[http://www.digitalinfo.net\]
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    xDefenders mailDefender - \[http://www.xdefenders.com\]
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Relay Services

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    Messagewash - \[http://www.messagewash.com\]
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Commercial Products That May Use SpamAssassin

(We're not sure about these; it's been suggested that they use SpamAssassin, but their public websites do not give any indication either way.)

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[MessageLabs] relay service \[http://www.messagelabs.com/\]  (JustinMason: do [MessageLabs] still use SA in their system?  I don't think they do, any more.)
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[BlackSpider] relay service \[http://www.blackspider.com/\]  (JustinMason: do [BlackSpider] use [SpamAssassin]?  There's no indication on their website that they do.)
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Moved to ThirdPartySoftware.